|
KMID : 0359920080270060738
|
|
Korean Journal of Nephrology
2008 Volume.27 No. 6 p.738 ~ p.742
|
|
|
A Case of Acute Interstitial Nephritis Complicated with Continuous Rifampin Therapy
|
|
Kim Hyeon-Jeong
Cha Jung-Min
Jung Duk-Eun
Lee Ji-Eun
Lee Yu-Min
Byun Seung-Jae
Song Ju-Heung
Ahn Seon-Ho
|
|
|
Abstract
|
|
|
Acute renal failure caused by rifampin typically occurs on intermittent administration or reintroduction of the drug. However, acute kidney injury (AKI) due to rifampin has been rarely reported to occur in patients receiving a continuous rifampin therapy. We have experienced a case of acute interstitial nephritis during the first course of standard anti-tuberculous therapy, including continuous rifampin therapy in daily dose. Forty-five-year-old male, who had been being treated with anti-tuberculous medication including rifampin (600 mg/day), was admitted to our hospital because of generalized
edema and dyspnea by acute renal failure. His past medical history was unremarkable. Since the creatinine level was still elevated in 10 days after cessation of rifampin, we performed renal biopsy. The renal pathologic findings revealed acute interstitial nephritis. After that, the patient symptom was relieved and serum creatinine level was decreased without specific therapy. The renal function was recovered at 1 month after withdrawal of rifampin. We report a case of acute interstitial nephritis complicated with the first daily rifampin therapy, along with the review of literature.
|
|
|
KEYWORD
|
|
|
Rifampin, Interstitial nephritis, Acute renal failure
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|